Peptide antibiotics are a unique class of antimicrobial agents composed of amino acid chains. While many traditional antibiotics are small molecules, these peptides often function by disrupting the physical integrity of bacterial cell membranes. They are categorized primarily into non-ribosomal peptides and antimicrobial peptides (AMPs).
Mechanism of Action: Pore Formation and Lysis
Many peptide antibiotics, such as Polymyxins and Daptomycin, utilize a "detergent-like" mechanism.
Binding: The positively charged (cationic) peptide is attracted to the negatively charged components of the bacterial cell wall (such as Lipopolysaccharides in Gram-negative bacteria).
Insertion: The peptide inserts its hydrophobic tail into the lipid bilayer.





